World Health Organisation (WHO) – analgesic ladder

The World Health Organization (WHO) has produced an analgesic ladder to be used as a guide for prescribing analgesics. Analgesics are staggered according to pain severity: mild, moderate and severe pain9. If a patient does not experience pain relief on one step of the analgesic ladder, they should progress to the next step.

  • Mild pain:                   Step 1: Simple analgesics (non-opioid)
    • Initiate topical and/or simple oral non-opioid analgesics (e.g. paracetamol, NSAIDs)
    • + adjuvant e.g. tricyclic antidepressants, anticonvulsants (pregabalin or gabapentin) for neuropathic pain.
  • Moderate pain:           Step 2: Weak opioid
    • Weak opioid (e.g. tramadol, codeine phosphate or dextropropoxyphene)
    • + adjuvant e.g. tricyclic antidepressants, anticonvulsants
  • Severe pain:                Step 3: Strong opioid
    • Opioids (e.g. morphine, oxycodone)
    • + adjuvant e.g. tricyclics, anticonvulsants

Adapted from WHO. Cancer Pain Relief, World Heath Organisation. Geneva. 19861,9.